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A Critical Role for Protein Kinase C-θ-Mediated T Cell Survival in Cardiac Allograft Rejection
Protein kinase C (PKC)-θ mediates the critical TCR signals required for T cell activation. Previously, we have shown that in response to TCR stimulation, PKC-θ(−/−) T cells undergo apoptosis due to greatly reduced levels of the anti-apoptotic molecule, Bcl-x(L). In this study, we demonstrate that PK...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2488962/ https://ncbi.nlm.nih.gov/pubmed/18566417 |
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