A Critical Role for Protein Kinase C-θ-Mediated T Cell Survival in Cardiac Allograft Rejection

Protein kinase C (PKC)-θ mediates the critical TCR signals required for T cell activation. Previously, we have shown that in response to TCR stimulation, PKC-θ(−/−) T cells undergo apoptosis due to greatly reduced levels of the anti-apoptotic molecule, Bcl-x(L). In this study, we demonstrate that PK...

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Bibliographic Details
Main Authors: Manicassamy, Santhakumar, Yin, Dengping, Zhang, Zheng, Molinero, Luciana L., Alegre, Marisa-Luisa, Sun, Zuoming
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2488962/
https://ncbi.nlm.nih.gov/pubmed/18566417
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