Co-deletion of the Ras GTPase-activating proteins Neurofibromin 1 (NF1) and p120 RasGAP (RASA1) in T cells results in the development of T cell acute lymphoblastic leukemia

Ras GTPase-activating proteins (RasGAPs) inhibit signal transduction initiated through the Ras small GTP-binding protein. However, which members of the RasGAP family act as negative regulators of T cell responses is not completely understood. Here, we investigated potential roles for the RasGAPs RAS...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Lubeck, Beth A., Lapinski, Philip E., Oliver, Jennifer A., Ksionda, Olga, Parada, Luis F., Zhu, Yuan, Maillard, Ivan, Chiang, Mark, Roose, Jeroen, King, Philip D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475412/
https://ncbi.nlm.nih.gov/pubmed/26002977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402639
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