Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia

Gain-of-function NOTCH1 mutations are found in 50%–70% of human T cell acute lymphoblastic leukemia/lymphoma (T-ALL) cases. Gain-of-function NOTCH1 alleles that initiate strong downstream signals induce leukemia in mice, but it is unknown whether the gain-of-function NOTCH1 mutations most commonly f...

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Bibliografski detalji
Glavni autori: Chiang, Mark Y., Xu, Lanwei, Shestova, Olga, Histen, Gavin, L’Heureux, Sarah, Romany, Candice, Childs, M. Eden, Gimotty, Phyllis A., Aster, Jon C., Pear, Warren S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2008
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491459/
https://ncbi.nlm.nih.gov/pubmed/18677410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35090
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