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Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells
The leukemia stem cell (LSC) hypothesis proposes that a subset of cells in the bulk leukemia population propagates the leukemia. We tested the LSC hypothesis in a mouse model of Notch-induced T-cell acute lymphoblastic leukemia (T-ALL) in which the tumor cells were largely CD4(+)CD8(+) T cells. LSC...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3567338/ https://ncbi.nlm.nih.gov/pubmed/23115273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-416503 |
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