Canonical Notch signaling is dispensable for the maintenance of adult hematopoietic stem cells

Gain-of-function experiments have demonstrated the potential of Notch signals to expand primitive hematopoietic progenitors, but whether Notch physiologically regulates hematopoietic stem cell (HSC) homeostasis in vivo is unclear. To answer this question, we evaluated the effect of global deficienci...

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Detalhes bibliográficos
Main Authors: Maillard, Ivan, Koch, Ute, Dumortier, Alexis, Shestova, Olga, Xu, Lanwei, Sai, Hong, Pross, Seth E., Aster, Jon C., Bhandoola, Avinash, Radtke, Freddy, Pear, Warren S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717373/
https://ncbi.nlm.nih.gov/pubmed/18397755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.02.011
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