The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre–T cell receptor

Genetic inactivation of Notch signaling in CD4(−)CD8(−) double-negative (DN) thymocytes was previously shown to impair T cell receptor (TCR) gene rearrangement and to cause a partial block in CD4(+)CD8(+) double-positive (DP) thymocyte development in mice. In contrast, in vitro cultures suggested th...

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Detalhes bibliográficos
Main Authors: Maillard, Ivan, Tu, LiLi, Sambandam, Arivazhagan, Yashiro-Ohtani, Yumi, Millholland, John, Keeshan, Karen, Shestova, Olga, Xu, Lanwei, Bhandoola, Avinash, Pear, Warren S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Brief Definitive Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118105/
https://ncbi.nlm.nih.gov/pubmed/16966428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061020
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