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Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells

The leukemia stem cell (LSC) hypothesis proposes that a subset of cells in the bulk leukemia population propagates the leukemia. We tested the LSC hypothesis in a mouse model of Notch-induced T-cell acute lymphoblastic leukemia (T-ALL) in which the tumor cells were largely CD4(+)CD8(+) T cells. LSC...

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Bibliografiske detaljer
Main Authors: Chiang, Mark Y., Shestova, Olga, Xu, Lanwei, Aster, Jon C., Pear, Warren S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567338/
https://ncbi.nlm.nih.gov/pubmed/23115273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-416503
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