Menin regulates the function of hematopoietic stem cells and lymphoid progenitors

Men1 is a tumor suppressor gene mutated in endocrine neoplasms. Besides its endocrine role, the Men1 gene product menin interacts with the mixed lineage leukemia (MLL) protein, a histone H3 lysine 4 methyltransferase. Although menin and MLL fusion proteins cooperate to activate Homeobox (Hox) gene e...

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Main Authors: Maillard, Ivan, Chen, Ya-Xiong, Friedman, Ann, Yang, Yuqing, Tubbs, Anthony T., Shestova, Olga, Pear, Warren S., Hua, Xianxin
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2009
Assuntos:
Hematopoiesis and Stem Cells
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647667/
https://ncbi.nlm.nih.gov/pubmed/19228930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-135012
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