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Notch Signaling in Leukemia

Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses what these mutations have taught us about normal and pathophysiologic Notch1 signaling, and how these insights may lead to n...

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Bibliografiska uppgifter
I publikationen:Annu Rev Pathol
Huvudupphovsmän: Aster, Jon C., Pear, Warren S., Blacklow, Stephen C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934586/
https://ncbi.nlm.nih.gov/pubmed/18039126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev.pathmechdis.3.121806.154300
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