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The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia

Notch is a major oncogenic driver in T cell acute lymphoblastic leukemia (T-ALL), in part because it binds to an enhancer that increases expression of MYC. Here, we exploit the capacity of activated NOTCH1 and NOTCH3 to induce T-ALL, despite substantial divergence in their intracellular regions, as...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Choi, Sung Hee, Severson, Eric, Pear, Warren S., Liu, Xiaole S., Aster, Jon C., Blacklow, Stephen C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638296/
https://ncbi.nlm.nih.gov/pubmed/29023469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185762
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