Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1

NOTCH1 is a large type I transmembrane receptor that regulates normal T-cell development via a signaling pathway that relies on regulated proteolysis. Ligand binding induces proteolytic cleavages in NOTCH1 that release its intracellular domain (ICN1), which translocates to the nucleus and activates...

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Main Authors: Chiang, Mark Y., Xu, Mina L., Histen, Gavin, Shestova, Olga, Roy, Monideepa, Nam, Yunsun, Blacklow, Stephen C., Sacks, David B., Pear, Warren S., Aster, Jon C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592797/
https://ncbi.nlm.nih.gov/pubmed/16880534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02478-05
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