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Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1
NOTCH1 is a large type I transmembrane receptor that regulates normal T-cell development via a signaling pathway that relies on regulated proteolysis. Ligand binding induces proteolytic cleavages in NOTCH1 that release its intracellular domain (ICN1), which translocates to the nucleus and activates...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1592797/ https://ncbi.nlm.nih.gov/pubmed/16880534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02478-05 |
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