Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1

NOTCH1 is a large type I transmembrane receptor that regulates normal T-cell development via a signaling pathway that relies on regulated proteolysis. Ligand binding induces proteolytic cleavages in NOTCH1 that release its intracellular domain (ICN1), which translocates to the nucleus and activates...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chiang, Mark Y., Xu, Mina L., Histen, Gavin, Shestova, Olga, Roy, Monideepa, Nam, Yunsun, Blacklow, Stephen C., Sacks, David B., Pear, Warren S., Aster, Jon C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2006
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592797/
https://ncbi.nlm.nih.gov/pubmed/16880534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02478-05
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