Notch Ankyrin Repeat Domain Variation Influences Leukemogenesis and Myc Transactivation

BACKGROUND: The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as cancer is unsettled. We used complementary in vivo, cell-based and structural analyses to compare the abilities of activated Notch1-4 to support T cell development, i...

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Detalhes bibliográficos
Main Authors: Aster, Jon C., Bodnar, Nick, Xu, Lanwei, Karnell, Fredrick, Milholland, John M., Maillard, Ivan, Histen, Gavin, Nam, Yunsun, Blacklow, Stephen C., Pear, Warren S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192765/
https://ncbi.nlm.nih.gov/pubmed/22022427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025645
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