Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias

Activating NOTCH1 mutations are found in 50–60% of human T-cell acute lymphoblastic leukemia (T-ALL) samples. In mouse models, these mutations generally fail to induce leukemia. This observation suggests that NOTCH1 activation must collaborate with other genetic events. Mutagenesis screens previousl...

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Detalhes bibliográficos
Main Authors: Rakowski, Lesley A., Garagiola, Derek D., Li, Choi M., Decker, Margaret, Caruso, Sarah, Jones, Morgan, Kuick, Rork, Cierpicki, Tomasz, Maillard, Ivan, Chiang, Mark Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549029/
https://ncbi.nlm.nih.gov/pubmed/23161489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1389
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