The phosphoinositide 3-kinase pathway and therapy resistance in cancer

Por Brown, Kristin K., Toker, Alex
Publicado no F1000Prime Rep (2015)

Adaptive Reprogramming of De Novo Pyrimidine Synthesis is a Metabolic Vulnerability in Triple-Negative Breast Cancer

Por Brown, Kristin K., Spinelli, Jessica B., Asara, John, Toker, Alex
Publicado no Cancer Discov (2017)

MERIT40 is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy

Por Brown, Kristin K., Montaser-Kouhsari, Laleh, Beck, Andrew H., Toker, Alex
Publicado no Cell Rep (2015)

PKD Controls αvβ3 Integrin Recycling and Tumor Cell Invasive Migration Through its Substrate Rabaptin-5

Por Christoforides, Claudine, Rainero, Elena, Brown, Kristin K., Norman, Jim C., Toker, Alex
Publicado em 2012

Approaches to target tractability assessment – a practical perspective

Por Brown, Kristin K., Hann, Michael M., Lakdawala, Ami S., Santos, Rita, Thomas, Pamela J., Todd, Kieran
Publicado no Medchemcomm (2018)

Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity.

Por Finger, Joshua N., Lich, John D., Dare, Lauren C., Cook, Michael N., Brown, Kristin K., Duraiswami, Chaya, Bertin, John, Gough, Peter J.
Publicado em 2012

Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity

Por Finger, Joshua N., Lich, John D., Dare, Lauren C., Cook, Michael N., Brown, Kristin K., Duraiswami, Chaya, Bertin, John J., Gough, Peter J.
Publicado em 2012

Direct Modification of the Proinflammatory Cytokine Macrophage Migration Inhibitory Factor by Dietary Isothiocyanates

Por Brown, Kristin K., Blaikie, Frances H., Smith, Robin A. J., Tyndall, Joel D. A., Lue, Hongqi, Bernhagen, Jürgen, Winterbourn, Christine C., Hampton, Mark B.
Publicado em 2009

S-nitrosothiol signaling regulates hepatogenesis and improves outcome following toxic liver injury

Por Cox, Andrew G., Saunders, Diane C., Kelsey, Peter, Conway, Allie A., Tesmenitsky, Yevgenia, Marchini, Julio F., Brown, Kristin K., Stamler, Jonathan S., Colagiovanni, Dorothy B., Rosenthal, Gary J., Croce, Kevin J., North, Trista E., Goessling, Wolfram
Publicado em 2014

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

Por Ma, Xiuquan, Zhang, Luxi, Song, Jiangning, Nguyen, Elizabeth, Lee, Rachel S., Rodgers, Samuel J., Li, Fuyi, Huang, Cheng, Schittenhelm, Ralf B., Chan, Howard, Chheang, Chanly, Wu, Jianmin, Brown, Kristin K., Mitchell, Christina A., Simpson, Kaylene J., Daly, Roger J.
Publicado no Nat Commun (2019)

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis

Por Cox, Andrew G., Tsomides, Allison, Kim, Andrew J., Saunders, Diane, Hwang, Katie L., Evason, Kimberley J., Heidel, Jerry, Brown, Kristin K., Yuan, Min, Lien, Evan C., Lee, Byung Cheon, Nissim, Sahar, Dickinson, Bryan, Chhangawala, Sagar, Chang, Christopher J., Asara, John M., Houvras, Yariv, Gladyshev, Vadim N., Goessling, Wolfram
Publicado no Proc Natl Acad Sci U S A (2016)

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

Por Cox, Andrew G., Hwang, Katie L., Brown, Kristin K., Evason, Kimberley, Beltz, Sebastian, Tsomides, Allison, O'Connor, Keelin, Galli, Giorgio G., Yimlamai, Dean, Chhangawala, Sagar, Yuan, Min, Lien, Evan C., Wucherpfennig, Julia, Nissim, Sahar, Minami, Akihiro, Cohen, David E., Camargo, Fernando D., Asara, John M., Houvras, Yariv, Stainier, Didier Y.R., Goessling, Wolfram
Publicado no Nat Cell Biol (2016)

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

Por Cox, Andrew G, Tsomides, Allison, Yimlamai, Dean, Hwang, Katie L, Miesfeld, Joel, Galli, Giorgio G, Fowl, Brendan H, Fort, Michael, Ma, Kimberly Y, Sullivan, Mark R, Hosios, Aaron M, Snay, Erin, Yuan, Min, Brown, Kristin K, Lien, Evan C, Chhangawala, Sagar, Steinhauser, Matthew L, Asara, John M, Houvras, Yariv, Link, Brian, Vander Heiden, Matthew G, Camargo, Fernando D, Goessling, Wolfram
Publicado no EMBO J (2018)

Sequence analysis of mutations and translocations across breast cancer subtypes

Por Banerji, Shantanu, Cibulskis, Kristian, Rangel-Escareno, Claudia, Brown, Kristin K., Carter, Scott L., Frederick, Abbie M., Lawrence, Michael S., Sivachenko, Andrey Y., Sougnez, Carrie, Zou, Lihua, Cortes, Maria L., Fernandez-Lopez, Juan C., Peng, Shouyong, Ardlie, Kristin G., Auclair, Daniel, Bautista-Piña, Veronica, Duke, Fujiko, Francis, Joshua, Jung, Joonil, Maffuz-Aziz, Antonio, Onofrio, Robert C., Parkin, Melissa, Pho, Nam H., Quintanar-Jurado, Valeria, Ramos, Alex H., Rebollar-Vega, Rosa, Rodriguez-Cuevas, Sergio, Romero-Cordoba, Sandra L., Schumacher, Steven E., Stransky, Nicolas, Thompson, Kristin M., Uribe-Figueroa, Laura, Baselga, Jose, Beroukhim, Rameen, Polyak, Kornelia, Sgroi, Dennis C., Richardson, Andrea L., Jimenez-Sanchez, Gerardo, Lander, Eric S., Gabriel, Stacey B., Garraway, Levi A., Golub, Todd R., Melendez-Zajgla, Jorge, Toker, Alex, Getz, Gad, Hidalgo-Miranda, Alfredo, Meyerson, Matthew
Publicado em 2012