Discovery and development of antiviral drugs for biodefense: Experience of a small biotechnology company

Por Bolken, Tove C., Hruby, Dennis E.
Publicado em 2008

The Vaccinia Virus I7L Gene Product Is The Core Protein Proteinase

Por Byrd, Chelsea M., Bolken, Tove' C., Hruby, Dennis E.
Publicado em 2002

Molecular Dissection of the Vaccinia Virus I7L Core Protein Proteinase

Por Byrd, Chelsea M., Bolken, Tove' C., Hruby, Dennis E.
Publicado em 2003

Conserved DegP Protease in Gram-Positive Bacteria Is Essential for Thermal and Oxidative Tolerance and Full Virulence in Streptococcus pyogenes

Por Jones, C. Hal, Bolken, Tove' C., Jones, Kevin F., Zeller, Gloria O., Hruby, Dennis E.
Publicado em 2001

Identification of a Broad-Spectrum Arenavirus Entry Inhibitor

Por Larson, Ryan A., Dai, Dongcheng, Hosack, Virginia T., Tan, Ying, Bolken, Tove’ C., Hruby, Dennis E., Amberg, Sean M.
Publicado em 2008

Inactivation of the srtA Gene in Streptococcus gordonii Inhibits Cell Wall Anchoring of Surface Proteins and Decreases In Vitro and In Vivo Adhesion

Por Bolken, Tové C., Franke, Christine A., Jones, Kevin F., Zeller, Gloria O., Jones, C. Hal, Dutton, Emma K., Hruby, Dennis E.
Publicado em 2001

Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice

Por Grosenbach, Douglas W., Berhanu, Aklile, King, David S., Mosier, Stacie, Jones, Kevin F., Jordan, Robert A., Bolken, Tove’ C., Hruby, Dennis E.
Publicado em 2009

Analysis of Factors Affecting Surface Expression and Immunogenicity of Recombinant Proteins Expressed by Gram-Positive Commensal Vectors

Por Bolken, Tové C., Franke, Christine A., Jones, Kevin F., Bell, Richard H., Swanson, Ryan M., King, David S., Fischetti, Vincent A., Hruby, Dennis E.
Publicado em 2002

Pharmacokinetics and Interspecies Allometric Scaling of ST-246, an Oral Antiviral Therapeutic for Treatment of Orthopoxvirus Infection

Por Amantana, Adams, Chen, Yali, Tyavanagimatt, Shanthakumar R., Jones, Kevin F., Jordan, Robert, Chinsangaram, Jarasvech, Bolken, Tove′ C., Leeds, Janet M., Hruby, Dennis E.
Publicado em 2013

Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus

Por Burgeson, James R., Gharaibeh, Dima N., Moore, Amy L., Larson, Ryan A., Amberg, Sean M., Bolken, Tove’ C., Hruby, Dennis E., Dai, Dongcheng
Publicado em 2013

Single-Dose Safety and Pharmacokinetics of ST-246, a Novel Orthopoxvirus Egress Inhibitor

Por Jordan, Robert, Tien, Deborah, Bolken, Tove' C., Jones, Kevin F., Tyavanagimatt, Shanthakumar R., Strasser, Josef, Frimm, Annie, Corrado, Michael L., Strome, Phoebe G., Hruby, Dennis E.
Publicado em 2008

New Class of Orthopoxvirus Antiviral Drugs That Block Viral Maturation

Por Byrd, Chelsea M., Bolken, Tove' C., Mjalli, Adnan M., Arimilli, Murty N., Andrews, Robert C., Rothlein, Robert, Andrea, Tariq, Rao, Mohan, Owens, Katrina L., Hruby, Dennis E.
Publicado em 2004

Safety and Pharmacokinetics of the Antiorthopoxvirus Compound ST-246 following Repeat Oral Dosing in Healthy Adult Subjects

Por Jordan, Robert, Chinsangaram, Jarasvech, Bolken, Tove' C., Tyavanagimatt, Shanthakumar R., Tien, Deborah, Jones, Kevin F., Frimm, Annie, Corrado, Michael L., Pickens, Margaret, Landis, Patrick, Clarke, Jean, Marbury, Thomas C., Hruby, Dennis E.
Publicado em 2010

Nonhuman Primates Are Protected from Smallpox Virus or Monkeypox Virus Challenges by the Antiviral Drug ST-246

Por Huggins, John, Goff, Arthur, Hensley, Lisa, Mucker, Eric, Shamblin, Josh, Wlazlowski, Carly, Johnson, Wendy, Chapman, Jennifer, Larsen, Tom, Twenhafel, Nancy, Karem, Kevin, Damon, Inger K., Byrd, Chelsea M., Bolken, Tove' C., Jordan, Robert, Hruby, Dennis
Publicado em 2009

Pharmacokinetic Comparison of a Single Oral Dose of Polymorph Form I versus Form V Capsules of the Antiorthopoxvirus Compound ST-246 in Human Volunteers

Por Chinsangaram, Jarasvech, Honeychurch, Kady M., Tyavanagimatt, Shanthakumar R., Bolken, Tove' C., Jordan, Robert, Jones, Kevin F., Marbury, Thomas, Lichtenstein, Israel, Pickens, Margaret, Corrado, Michael, Landis, Patrick, Clarke, Jean M., Frimm, Annie M., Hruby, Dennis E.
Publicado em 2012

Evaluation of Lassa antiviral compound ST-193 in a guinea pig model

Por Cashman, Kathleen A., Smith, Mark A., Twenhafel, Nancy A., Larson, Ryan A., Jones, Kevin F., Allen, Robert D., Dai, Dongcheng, Chinsangaram, Jarasvech, Bolken, Tove’ C., Hruby, Dennis E., Amberg, Sean M., Hensley, Lisa E., Guttieri, Mary C.
Publicado em 2011

ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification

Por Jordan, Robert, Goff, Arthur, Frimm, Annie, Corrado, Michael L., Hensley, Lisa E., Byrd, Chelsea M., Mucker, Eric, Shamblin, Josh, Bolken, Tove' C., Wlazlowski, Carly, Johnson, Wendy, Chapman, Jennifer, Twenhafel, Nancy, Tyavanagimatt, Shanthakumar, Amantana, Adams, Chinsangaram, Jarasvech, Hruby, Dennis E., Huggins, John
Publicado em 2009

Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers

Por Chinsangaram, Jarasvech, Honeychurch, Kady M., Tyavanagimatt, Shanthakumar R., Leeds, Janet M., Bolken, Tove' C., Jones, Kevin F., Jordan, Robert, Marbury, Thomas, Ruckle, Jon, Mee-Lee, Denis, Ross, Eric, Lichtenstein, Israel, Pickens, Margaret, Corrado, Michael, Clarke, Jean M., Frimm, Annie M., Hruby, Dennis E.
Publicado em 2012