Safety and Pharmacokinetics of the Antiorthopoxvirus Compound ST-246 following Repeat Oral Dosing in Healthy Adult Subjects

ST-246, a novel compound that inhibits egress of orthopoxvirus from infected cells, is being evaluated as a treatment for pathogenic orthopoxvirus infections in humans. This phase I, double-blind, randomized, placebo-controlled, escalating multiple-dose study was conducted to determine the safety, t...

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Autori principali: Jordan, Robert, Chinsangaram, Jarasvech, Bolken, Tove' C., Tyavanagimatt, Shanthakumar R., Tien, Deborah, Jones, Kevin F., Frimm, Annie, Corrado, Michael L., Pickens, Margaret, Landis, Patrick, Clarke, Jean, Marbury, Thomas C., Hruby, Dennis E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876426/
https://ncbi.nlm.nih.gov/pubmed/20385870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01689-09
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