Pharmacokinetics and Interspecies Allometric Scaling of ST-246, an Oral Antiviral Therapeutic for Treatment of Orthopoxvirus Infection

Plasma pharmacokinetics of ST-246, smallpox therapeutic, was evaluated in mice, rabbits, monkeys and dogs following repeat oral administrations by gavage. The dog showed the lowest T(max) of 0.83 h and the monkey, the highest value of 3.25 h. A 2- to 4-fold greater dose-normalized C(max) was observe...

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Main Authors: Amantana, Adams, Chen, Yali, Tyavanagimatt, Shanthakumar R., Jones, Kevin F., Jordan, Robert, Chinsangaram, Jarasvech, Bolken, Tove′ C., Leeds, Janet M., Hruby, Dennis E.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630197/
https://ncbi.nlm.nih.gov/pubmed/23637845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061514
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