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Pharmacokinetics and Interspecies Allometric Scaling of ST-246, an Oral Antiviral Therapeutic for Treatment of Orthopoxvirus Infection
Plasma pharmacokinetics of ST-246, smallpox therapeutic, was evaluated in mice, rabbits, monkeys and dogs following repeat oral administrations by gavage. The dog showed the lowest T(max) of 0.83 h and the monkey, the highest value of 3.25 h. A 2- to 4-fold greater dose-normalized C(max) was observe...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3630197/ https://ncbi.nlm.nih.gov/pubmed/23637845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061514 |
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