ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification

Therapeutics for the treatment of pathogenic orthopoxvirus infections are being sought. In the absence of patients with disease, animal models of orthopoxvirus disease are essential for evaluation of the efficacies of antiviral drugs and establishment of the appropriate dose and duration of human th...

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Main Authors: Jordan, Robert, Goff, Arthur, Frimm, Annie, Corrado, Michael L., Hensley, Lisa E., Byrd, Chelsea M., Mucker, Eric, Shamblin, Josh, Bolken, Tove' C., Wlazlowski, Carly, Johnson, Wendy, Chapman, Jennifer, Twenhafel, Nancy, Tyavanagimatt, Shanthakumar, Amantana, Adams, Chinsangaram, Jarasvech, Hruby, Dennis E., Huggins, John
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681496/
https://ncbi.nlm.nih.gov/pubmed/19223621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01596-08
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