ST-246 Antiviral Efficacy in a Nonhuman Primate Monkeypox Model: Determination of the Minimal Effective Dose and Human Dose Justification

Therapeutics for the treatment of pathogenic orthopoxvirus infections are being sought. In the absence of patients with disease, animal models of orthopoxvirus disease are essential for evaluation of the efficacies of antiviral drugs and establishment of the appropriate dose and duration of human th...

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Detalhes bibliográficos
Main Authors: Jordan, Robert, Goff, Arthur, Frimm, Annie, Corrado, Michael L., Hensley, Lisa E., Byrd, Chelsea M., Mucker, Eric, Shamblin, Josh, Bolken, Tove' C., Wlazlowski, Carly, Johnson, Wendy, Chapman, Jennifer, Twenhafel, Nancy, Tyavanagimatt, Shanthakumar, Amantana, Adams, Chinsangaram, Jarasvech, Hruby, Dennis E., Huggins, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681496/
https://ncbi.nlm.nih.gov/pubmed/19223621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01596-08
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