Pharmacokinetic Comparison of a Single Oral Dose of Polymorph Form I versus Form V Capsules of the Antiorthopoxvirus Compound ST-246 in Human Volunteers

ST-246, a novel compound that inhibits egress of orthopoxvirus from mammalian cells, is being tested as a treatment for pathogenic orthopoxvirus infections in humans. This phase I, double-blind, randomized, crossover, exploratory study was conducted to compare the pharmacokinetics (PK) of a single d...

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Hlavní autoři: Chinsangaram, Jarasvech, Honeychurch, Kady M., Tyavanagimatt, Shanthakumar R., Bolken, Tove' C., Jordan, Robert, Jones, Kevin F., Marbury, Thomas, Lichtenstein, Israel, Pickens, Margaret, Corrado, Michael, Landis, Patrick, Clarke, Jean M., Frimm, Annie M., Hruby, Dennis E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393399/
https://ncbi.nlm.nih.gov/pubmed/22526314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06090-11
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