Pharmacokinetic Comparison of a Single Oral Dose of Polymorph Form I versus Form V Capsules of the Antiorthopoxvirus Compound ST-246 in Human Volunteers

ST-246, a novel compound that inhibits egress of orthopoxvirus from mammalian cells, is being tested as a treatment for pathogenic orthopoxvirus infections in humans. This phase I, double-blind, randomized, crossover, exploratory study was conducted to compare the pharmacokinetics (PK) of a single d...

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Autors principals: Chinsangaram, Jarasvech, Honeychurch, Kady M., Tyavanagimatt, Shanthakumar R., Bolken, Tove' C., Jordan, Robert, Jones, Kevin F., Marbury, Thomas, Lichtenstein, Israel, Pickens, Margaret, Corrado, Michael, Landis, Patrick, Clarke, Jean M., Frimm, Annie M., Hruby, Dennis E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393399/
https://ncbi.nlm.nih.gov/pubmed/22526314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06090-11
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