Pharmacokinetic and Pharmacodynamic Modeling To Determine the Dose of ST-246 To Protect against Smallpox in Humans

Although smallpox has been eradicated, the United States government considers it a “material threat” and has funded the discovery and development of potential therapeutic compounds. As reported here, the human efficacious dose for one of these compounds, ST-246, was determined using efficacy studies...

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Bibliographic Details
Main Authors: Leeds, Janet M., Fenneteau, Frederique, Gosselin, Nathalie H., Mouksassi, Mohamad-Samer, Kassir, Nastya, Marier, J. F., Chen, Yali, Grosenbach, Doug, Frimm, Annie E., Honeychurch, Kady M., Chinsangaram, Jarasvech, Tyavanagimatt, Shanthakumar R., Hruby, Dennis E., Jordan, Robert
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591874/
https://ncbi.nlm.nih.gov/pubmed/23254433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00959-12
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