Pharmacokinetic Comparison of a Single Oral Dose of Polymorph Form I versus Form V Capsules of the Antiorthopoxvirus Compound ST-246 in Human Volunteers

ST-246, a novel compound that inhibits egress of orthopoxvirus from mammalian cells, is being tested as a treatment for pathogenic orthopoxvirus infections in humans. This phase I, double-blind, randomized, crossover, exploratory study was conducted to compare the pharmacokinetics (PK) of a single d...

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Hauptverfasser: Chinsangaram, Jarasvech, Honeychurch, Kady M., Tyavanagimatt, Shanthakumar R., Bolken, Tove' C., Jordan, Robert, Jones, Kevin F., Marbury, Thomas, Lichtenstein, Israel, Pickens, Margaret, Corrado, Michael, Landis, Patrick, Clarke, Jean M., Frimm, Annie M., Hruby, Dennis E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393399/
https://ncbi.nlm.nih.gov/pubmed/22526314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06090-11
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