Analysis of Factors Affecting Surface Expression and Immunogenicity of Recombinant Proteins Expressed by Gram-Positive Commensal Vectors

Several key protein structural attributes were altered in an effort to optimize expression and immunogenicity of a foreign protein (M protein from Streptococcus pyogenes) exposed on the surface of Streptococcus gordonii commensal bacterial vectors: (i) a shorter N-terminal region, (ii) the addition...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Bolken, Tové C., Franke, Christine A., Jones, Kevin F., Bell, Richard H., Swanson, Ryan M., King, David S., Fischetti, Vincent A., Hruby, Dennis E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Microbial Immunity and Vaccines
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127933/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11953386/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.5.2487-2491.2002
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