Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus

Previously we reported the optimization of antiviral scaffolds containing benzimidazole and related heterocycles possessing activity against a variety of arenaviruses. These series of compounds were discovered through an HTS campaign of a 400,000 small molecule library using lentivirus-based pseudot...

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Bibliografiske detaljer
Main Authors: Burgeson, James R., Gharaibeh, Dima N., Moore, Amy L., Larson, Ryan A., Amberg, Sean M., Bolken, Tove’ C., Hruby, Dennis E., Dai, Dongcheng
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836667/
https://ncbi.nlm.nih.gov/pubmed/24064500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.08.103
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