Ras-Mek-Erk Signaling Regulates Nf1 Heterozygous Neointima Formation

by Stansfield, Brian K., Bessler, Waylan K., Mali, Raghuveer, Mund, Julie A., Downing, Brandon D., Kapur, Reuben, Ingram, David A.
Published 2014

Nf1+/− mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathway

by Lasater, Elisabeth A., Bessler, Waylan K., Mead, Laura E., Horn, Whitney E., Clapp, D. Wade, Conway, Simon J., Ingram, David A., Li, Fang
Published 2008

Irradiation of Nf1 mutant mouse models of spinal plexiform neurofibromas drives pathologic progression and decreases survival

by Laurent, Danny, Smith, Abbi E, Bessler, Waylan K, Mendonca, Marc, Chin-Sinex, Helen, Descovich, Martina, Horvai, Andrew E, Clapp, D Wade, Nakamura, Jean L
Published in Neurooncol Adv (2021)

Nf1(+/−) monocytes/macrophages induce neointima formation via CCR2 activation

by Bessler, Waylan K., Kim, Grace, Hudson, Farlyn Z., Mund, Julie A., Mali, Raghuveer, Menon, Keshav, Kapur, Reuben, Clapp, D. Wade, Ingram, David A., Stansfield, Brian K.
Published in Hum Mol Genet (2016)

Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans

by Lasater, Elisabeth A., Li, Fang, Bessler, Waylan K., Estes, Myka L., Vemula, Sasidhar, Hingtgen, Cynthia M., Dinauer, Mary C., Kapur, Reuben, Conway, Simon J., Ingram, David A.
Published 2010

Neurofibromin is a novel regulator of Ras-induced reactive oxygen species production in mice and humans

by Bessler, Waylan K., Hudson, Farlyn Z., Zhang, Hanfang, Harris, Valerie, Wang, Yusi, Mund, Julie A., Downing, Brandon, Ingram, David A., Case, Jamie, Fulton, David J., Stansfield, Brian K.
Published in Free Radic Biol Med (2016)

Heterozygous inactivation of the Nf1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway

by Stansfield, Brian K., Bessler, Waylan K., Mali, Raghuveer, Mund, Julie A., Downing, Brandon, Li, Fang, Sarchet, Kara N., DiStasi, Matthew R., Conway, Simon J., Kapur, Reuben, Ingram, David A.
Published 2013

Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1(+/−) mast cells

by McDaniel, Andrew S., Allen, Jayme D., Park, Su-Jung, Jaffer, Zahara M, Michels, Elizabeth G., Burgin, Sarah J., Chen, Shi, Bessler, Waylan K., Hofmann, Clemens, Ingram, David A., Chernoff, Jonathan, Clapp, D. Wade
Published 2008

Ketotifen Modulates Mast Cell Chemotaxis to Kit-Ligand, but Does Not Impact Mast Cell Numbers, Degranulation, or Tumor Behavior in Neurofibromas of Nf1- Deficient Mice

by Burks, Ciersten A., Rhodes, Steven D., Bessler, Waylan K., Chen, Shi, Smith, Abbi, Gehlhausen, Jeffrey R., Hawley, Eric T., Jiang, Li, Li, Xiaohong, Yuan, Jin, Lu, Qingbo, Jacobsen, Max, Sandusky, George, Jones, David R., Clapp, D. Wade, Blakeley, Jaishri
Published in Mol Cancer Ther (2019)

Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 1

by Mund, Julie A., Park, SuJung, Smith, Abbi E., He, Yongzheng, Jiang, Li, Hawley, Eric, Roberson, Michelle J., Mitchell, Dana K., Abu-Sultanah, Mohannad, Yuan, Jin, Bessler, Waylan K., Sandusky, George, Chen, Shi, Zhang, Chi, Rhodes, Steven D., Clapp, D. Wade
Published in J Biol Chem (2020)

Correction: Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17

by Mund, Julie A., Park, SuJung, Smith, Abbi E., He, Yongzheng, Jiang, Li, Hawley, Eric, Roberson, Michelle J., Mitchell, Dana K., Abu-Sultanah, Mohannad, Yuan, Jin, Bessler, Waylan K., Sandusky, George, Chen, Shi, Zhang, Chi, Rhodes, Steven D., Clapp, D. Wade
Published in J Biol Chem (2020)

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics

by Allen, Jayme D., Jaffer, Zahara M., Park, Su-Jung, Burgin, Sarah, Hofmann, Clemens, Sells, Mary Ann, Chen, Shi, Derr-Yellin, Ethel, Michels, Elizabeth G., McDaniel, Andrew, Bessler, Waylan K., Ingram, David A., Atkinson, Simon J., Travers, Jeffrey B., Chernoff, Jonathan, Clapp, D. Wade
Published 2009

Neurofibromin Deficient Myeloid Cells are Critical Mediators of Aneurysm Formation In Vivo

by Li, Fang, Downing, Brandon D., Smiley, Lucy C., Mund, Julie A., DiStasi, Matthew R., Bessler, Waylan K., Sarchet, Kara N., Hinds, Daniel M., Kamendulis, Lisa M., Hingtgen, Cynthia M., Case, Jamie, Clapp, D. Wade, Conway, Simon J., Stansfield, Brian K., Ingram, David A.
Published 2013

Cabozantinib for neurofibromatosis type 1-related plexiform neurofibromas: a phase 2 trial

by Fisher, Michael J., Shih, Chie-Schin, Rhodes, Steven D., Armstrong, Amy E., Wolters, Pamela L., Dombi, Eva, Zhang, Chi, Angus, Steven P., Johnson, Gary L., Packer, Roger J., Allen, Jeffrey C., Ullrich, Nicole J., Goldman, Stewart, Gutmann, David H., Plotkin, Scott R., Rosser, Tena, Robertson, Kent A., Widemann, Brigitte C., Smith, Abbi E., Bessler, Waylan K., He, Yongzheng, Park, Su-Jung, Mund, Julie A., Jiang, Li, Bijangi-Vishehsaraei, Khadijeh, Robinson, Coretta Thomas, Cutter, Gary R., Korf, Bruce R., Blakeley, Jaishri O., Clapp, D. Wade
Published in Nat Med (2021)

Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK

by Chang, Long-Sheng, Oblinger, Janet L., Smith, Abbi E., Ferrer, Marc, Angus, Steven P., Hawley, Eric, Petrilli, Alejandra M., Beauchamp, Roberta L., Riecken, Lars Björn, Erdin, Serkan, Poi, Ming, Huang, Jie, Bessler, Waylan K., Zhang, Xiaohu, Guha, Rajarshi, Thomas, Craig, Burns, Sarah S., Gilbert, Thomas S. K., Jiang, Li, Li, Xiaohong, Lu, Qingbo, Yuan, Jin, He, Yongzheng, Dixon, Shelley A. H., Masters, Andrea, Jones, David R., Yates, Charles W., Haggarty, Stephen J., La Rosa, Salvatore, Welling, D. Bradley, Stemmer-Rachamimov, Anat O., Plotkin, Scott R., Gusella, James F., Guinney, Justin, Morrison, Helen, Ramesh, Vijaya, Fernandez-Valle, Cristina, Johnson, Gary L., Blakeley, Jaishri O., Clapp, D. Wade
Published in PLoS One (2021)