Nf1+/− mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathway

Neurofibromatosis type I (NF1) is a genetic disorder caused by mutations in the NF1 tumor suppressor gene. Neurofibromin is encoded by NF1 and functions as a negative regulator of Ras activity. Somatic mutations in the residual normal NF1 allele within cancers of NF1 patients is consistent with NF1...

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Hauptverfasser: Lasater, Elisabeth A., Bessler, Waylan K., Mead, Laura E., Horn, Whitney E., Clapp, D. Wade, Conway, Simon J., Ingram, David A., Li, Fang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2008
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733812/
https://ncbi.nlm.nih.gov/pubmed/18442999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn134
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