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Nf1(+/−) monocytes/macrophages induce neointima formation via CCR2 activation
Persons with neurofibromatosis type 1 (NF1) have a predisposition for premature and severe arterial stenosis. Mutations in the NF1 gene result in decreased expression of neurofibromin, a negative regulator of p21(Ras), and increases Ras signaling. Heterozygous Nf1 (Nf1(+/−)) mice develop a marked ar...
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| Foilsithe in: | Hum Mol Genet |
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| Main Authors: | , , , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Oxford University Press
2016
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4764194/ https://ncbi.nlm.nih.gov/pubmed/26740548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv635 |
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