Nf1(+/−) monocytes/macrophages induce neointima formation via CCR2 activation

Persons with neurofibromatosis type 1 (NF1) have a predisposition for premature and severe arterial stenosis. Mutations in the NF1 gene result in decreased expression of neurofibromin, a negative regulator of p21(Ras), and increases Ras signaling. Heterozygous Nf1 (Nf1(+/−)) mice develop a marked ar...

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Udgivet i:Hum Mol Genet
Main Authors: Bessler, Waylan K., Kim, Grace, Hudson, Farlyn Z., Mund, Julie A., Mali, Raghuveer, Menon, Keshav, Kapur, Reuben, Clapp, D. Wade, Ingram, David A., Stansfield, Brian K.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764194/
https://ncbi.nlm.nih.gov/pubmed/26740548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv635
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