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Nf1+/− mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathway
Neurofibromatosis type I (NF1) is a genetic disorder caused by mutations in the NF1 tumor suppressor gene. Neurofibromin is encoded by NF1 and functions as a negative regulator of Ras activity. Somatic mutations in the residual normal NF1 allele within cancers of NF1 patients is consistent with NF1...
Tallennettuna:
| Päätekijät: | , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2008
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2733812/ https://ncbi.nlm.nih.gov/pubmed/18442999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn134 |
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