Neurofibromin Deficient Myeloid Cells are Critical Mediators of Aneurysm Formation In Vivo

BACKGROUND: Neurofibromatosis Type 1 (NF1) is a genetic disorder resulting from mutations in the NF1 tumor suppressor gene. Neurofibromin, the protein product of NF1, functions as a negative regulator of Ras activity in circulating hematopoietic and vascular wall cells, which are critical for mainta...

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Hauptverfasser: Li, Fang, Downing, Brandon D., Smiley, Lucy C., Mund, Julie A., DiStasi, Matthew R., Bessler, Waylan K., Sarchet, Kara N., Hinds, Daniel M., Kamendulis, Lisa M., Hingtgen, Cynthia M., Case, Jamie, Clapp, D. Wade, Conway, Simon J., Stansfield, Brian K., Ingram, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960343/
https://ncbi.nlm.nih.gov/pubmed/24370551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.006320
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