p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics

Mast cells are key participants in allergic diseases via activation of high-affinity IgE receptors (FcϵRI) resulting in release of proinflammatory mediators. The biochemical pathways linking IgE activation to calcium influx and cytoskeletal changes required for intracellular granule release are inco...

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Detalhes bibliográficos
Main Authors: Allen, Jayme D., Jaffer, Zahara M., Park, Su-Jung, Burgin, Sarah, Hofmann, Clemens, Sells, Mary Ann, Chen, Shi, Derr-Yellin, Ethel, Michels, Elizabeth G., McDaniel, Andrew, Bessler, Waylan K., Ingram, David A., Atkinson, Simon J., Travers, Jeffrey B., Chernoff, Jonathan, Clapp, D. Wade
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661857/
https://ncbi.nlm.nih.gov/pubmed/19124833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-160861
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