Functionalizing genomic data for personalization of medicine

Por Benes, Cyril H.
Publicado em 2012

Direct pharmacological assessment of clinically acquired models as a strategy to overcome resistance to tyrosine kinase inhibitors

Por Benes, Cyril H
Publicado no Mol Cell Oncol (2015)

EMT Twists the road to PI3Kinase

Por Niederst, Matthew J., Benes, Cyril H.
Publicado em 2014

P2X(7) Receptor Antagonists Display Agonist-like Effects on Cell Signaling Proteins

Por Hedden, Lee, Benes, Cyril H., Soltoff, Stephen P.
Publicado em 2011

Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

Por Buisson, Rémi, Boisvert, Jessica L., Benes, Cyril H., Zou, Lee
Publicado no Mol Cell (2015)

Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties

Por Menden, Michael P., Iorio, Francesco, Garnett, Mathew, McDermott, Ultan, Benes, Cyril H., Ballester, Pedro J., Saez-Rodriguez, Julio
Publicado em 2013

CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers

Por Heilmann, Andreas M., Perera, Rushika M., Ecker, Veronika, Nicolay, Brandon N., Bardeesy, Nabeel, Benes, Cyril H., Dyson, Nicholas J.
Publicado em 2014

Drug/Cell-line Browser: interactive canvas visualization of cancer drug/cell-line viability assay datasets

Por Duan, Qiaonan, Wang, Zichen, Fernandez, Nicolas F., Rouillard, Andrew D., Tan, Christopher M., Benes, Cyril H., Ma’ayan, Avi
Publicado no Bioinformatics (2014)

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis

Por Corcoran, Ryan B., Contino, Gianmarco, Deshpande, Vikram, Tzatsos, Alexandros, Conrad, Claudius, Benes, Cyril H., Settleman, Jeffrey, Engelman, Jeffrey A., Bardeesy, Nabeel
Publicado em 2011

Lysine Demethylase KDM4A Associates with Translation Machinery and Regulates Protein Synthesis

Por Van Rechem, Capucine, Black, Joshua C., Boukhali, Myriam, Aryee, Martin J., Gräslund, Susanne, Haas, Wilhelm, Benes, Cyril H., Whetstine, Johnathan R.
Publicado no Cancer Discov (2015)

Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma

Por He, Lei, Torres-Lockhart, Kristine, Forster, Nicole, Ramakrishnan, Saranya, Greninger, Patricia, Garnett, Mathew J., McDermott, Ultan, Rothenberg, S. Michael, Benes, Cyril H., Ellisen, Leif W.
Publicado em 2012

EGFR activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity

Por Pfäffle, Heike N., Wang, Meng, Gheorghiu, Liliana, Ferraiolo, Natalie, Greninger, Patricia, Borgmann, Kerstin, Settleman, Jeffrey, Benes, Cyril H., Sequist, Lecia V., Zou, Lee, Willers, Henning
Publicado em 2013

A Coding Single Nucleotide Polymorphism in Lysine Demethylase KDM4A Increases Sensitivity to mTOR Inhibitors

Por Van Rechem, Capucine, Black, Joshua C., Greninger, Patricia, Zhao, Yang, Donado, Carlos, Burrowes, Paul d., Ladd, Brendon, Christiani, David C., Benes, Cyril H., Whetstine, Johnathan R.
Publicado no Cancer Discov (2015)

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1

Por Ebi, Hiromichi, Costa, Carlotta, Faber, Anthony C., Nishtala, Madhuri, Kotani, Hiroshi, Juric, Dejan, Della Pelle, Patricia, Song, Youngchul, Yano, Seiji, Mino-Kenudson, Mari, Benes, Cyril H., Engelman, Jeffrey A.
Publicado em 2013

EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells Against Ionizing Radiation

Por Wang, Meng, Kern, Ashley M., Hülskötter, Marieke, Greninger, Patricia, Singh, Anurag, Pan, Yunfeng, Chowdhury, Dipanjan, Krause, Mechthild, Baumann, Michael, Benes, Cyril H., Efstathiou, Jason A., Settleman, Jeff, Willers, Henning
Publicado no Cancer Res (2014)

Adapting a Drug Screening Platform to Discover Associations of Molecular Targeted Radiosensitizers with Genomic Biomarkers

Por Liu, Qi, Wang, Meng, Kern, Ashley M., Khaled, Saman, Han, Jing, Yeap, Beow Y., Hong, Theodore S., Settleman, Jeff, Benes, Cyril H., Held, Kathryn D., Efstathiou, Jason A., Willers, Henning
Publicado no Mol Cancer Res (2015)

Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anti-cancer agent

Por Ni, Jing, Liu, Qingsong, Xie, Shaozhen, Carlson, Coby B., Von, Thanh, Vogel, Kurt W., Riddle, Steve M., Benes, Cyril H., Eck, Michael J., Roberts, Thomas M, Gray, Nathanael S., Zhao, Jean J.
Publicado em 2012

Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing’s Sarcoma

Por Gill, Sonja J., Travers, Jon, Pshenichnaya, Irina, Kogera, Fiona A., Barthorpe, Syd, Mironenko, Tatiana, Richardson, Laura, Benes, Cyril H., Stratton, Michael R., McDermott, Ultan, Jackson, Stephen P., Garnett, Mathew J.
Publicado no PLoS One (2015)

Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients

Por Emerling, Brooke M., Benes, Cyril H., Poulogiannis, George, Bell, Eric L., Courtney, Kevin, Liu, Hui, Choo-Wing, Rayman, Bellinger, Gary, Tsukazawa, Kazumi S., Brown, Victoria, Signoretti, Sabina, Soltoff, Stephen P., Cantley, Lewis C.
Publicado em 2013

Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer

Por Alagesan, Brinda, Contino, Gianmarco, Guimaraes, Alex R., Corcoran, Ryan B., Deshpande, Vikram, Wojtkiewicz, Gregory R., Hezel, Aram F., Wong, Kwok-Kin, Loda, Massimo, Weissleder, Ralph, Benes, Cyril H., Engelman, Jeffrey, Bardeesy, Nabeel
Publicado no Clin Cancer Res (2014)