Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer

PURPOSE: Improved therapeutic approaches are needed for the treatment of pancreatic ductal adenocarcinoma (PDAC). As dual MEK and PI3K inhibition is presently being employed in clinical trials for PDAC patients, we sought to test the efficacy of combined targeting of these pathways in PDAC using bot...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Alagesan, Brinda, Contino, Gianmarco, Guimaraes, Alex R., Corcoran, Ryan B., Deshpande, Vikram, Wojtkiewicz, Gregory R., Hezel, Aram F., Wong, Kwok-Kin, Loda, Massimo, Weissleder, Ralph, Benes, Cyril H., Engelman, Jeffrey, Bardeesy, Nabeel
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447091/
https://ncbi.nlm.nih.gov/pubmed/25348516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1591
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