Lysine-specific Demethylase 2B (KDM2B)-let-7-Enhancer of Zester Homolog 2 (EZH2) Pathway Regulates Cell Cycle Progression and Senescence in Primary Cells

Sustained expression of the histone demethylase, KDM2B (Ndy1/FBXL10/JHDM1B), bypasses cellular senescence in primary mouse embryonic fibroblasts (MEFs). Here, we show that KDM2B is a conserved regulator of lifespan in multiple primary cell types and defines a program in which this chromatin-modifyin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tzatsos, Alexandros, Paskaleva, Polina, Lymperi, Stephania, Contino, Gianmarco, Stoykova, Svetlana, Chen, Zhao, Wong, Kwok-Kin, Bardeesy, Nabeel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Gene Regulation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190920/
https://ncbi.nlm.nih.gov/pubmed/21757686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.257667
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