KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs

Epigenetic mechanisms mediate heritable control of cell identity in normal cells and cancer. We sought to identify epigenetic regulators driving the pathogenesis of pancreatic ductal adenocarcinoma (PDAC), one of the most lethal human cancers. We found that KDM2B (also known as Ndy1, FBXL10, and JHD...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tzatsos, Alexandros, Paskaleva, Polina, Ferrari, Francesco, Deshpande, Vikram, Stoykova, Svetlana, Contino, Gianmarco, Wong, Kwok-Kin, Lan, Fei, Trojer, Patrick, Park, Peter J., Bardeesy, Nabeel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2013
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561797/
https://ncbi.nlm.nih.gov/pubmed/23321669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64535
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