KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs

Epigenetic mechanisms mediate heritable control of cell identity in normal cells and cancer. We sought to identify epigenetic regulators driving the pathogenesis of pancreatic ductal adenocarcinoma (PDAC), one of the most lethal human cancers. We found that KDM2B (also known as Ndy1, FBXL10, and JHD...

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Detalhes bibliográficos
Main Authors: Tzatsos, Alexandros, Paskaleva, Polina, Ferrari, Francesco, Deshpande, Vikram, Stoykova, Svetlana, Contino, Gianmarco, Wong, Kwok-Kin, Lan, Fei, Trojer, Patrick, Park, Peter J., Bardeesy, Nabeel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561797/
https://ncbi.nlm.nih.gov/pubmed/23321669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64535
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