TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progression

The TGFβ pathway is under active consideration as a cancer drug target based on its capacity to promote cancer cell invasion and to create a pro-tumorigenic microenvironment. However, the clinical application of TGFβ inhibitors remains uncertain as genetic studies demonstrate a tumor suppressor func...

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Bibliografiske detaljer
Main Authors: Hezel, Aram F., Deshpande, Vikram, Zimmerman, Stephanie M., Contino, Gianmarco, Alagesan, Brinda, O’Dell, Michael R., Rivera, Lee B., Harper, Jay, Lonning, Scott, Brekken, Rolf A., Bardeesy, Nabeel
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764481/
https://ncbi.nlm.nih.gov/pubmed/22787119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0634
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