TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?

INTRODUCTION: The pathophysiology of systemic sclerosis (SSc) is closely linked to overactive TGFβ signaling. TGFβ is produced and circulates in latent form, making its activation crucial for signaling. This activation can be mediated via integrins. We investigated the balance between active and lat...

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Detaylı Bibliyografya
Yayımlandı:Arthritis Res Ther
Asıl Yazarlar: van Caam, A., Aarts, J., van Ee, T., Vitters, E., Koenders, M., van de Loo, F., van Lent, P., van den Hoogen, F., Thurlings, R., Vonk, M. C., van der Kraan, P. M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059334/
https://ncbi.nlm.nih.gov/pubmed/32143707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-020-2130-5
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