TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?

INTRODUCTION: The pathophysiology of systemic sclerosis (SSc) is closely linked to overactive TGFβ signaling. TGFβ is produced and circulates in latent form, making its activation crucial for signaling. This activation can be mediated via integrins. We investigated the balance between active and lat...

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Pubblicato in:Arthritis Res Ther
Autori principali: van Caam, A., Aarts, J., van Ee, T., Vitters, E., Koenders, M., van de Loo, F., van Lent, P., van den Hoogen, F., Thurlings, R., Vonk, M. C., van der Kraan, P. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059334/
https://ncbi.nlm.nih.gov/pubmed/32143707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-020-2130-5
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