A Coding Single Nucleotide Polymorphism in Lysine Demethylase KDM4A Increases Sensitivity to mTOR Inhibitors

Single nucleotide polymorphisms (SNPs) occur within chromatin-modulating factors; however, little is known about how these variants within the coding sequence impact cancer progression or treatment. Therefore, there is a need to establish their biochemical and/or molecular contribution, their use in...

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Bibliographic Details
Published in:Cancer Discov
Main Authors: Van Rechem, Capucine, Black, Joshua C., Greninger, Patricia, Zhao, Yang, Donado, Carlos, Burrowes, Paul d., Ladd, Brendon, Christiani, David C., Benes, Cyril H., Whetstine, Johnathan R.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355226/
https://ncbi.nlm.nih.gov/pubmed/25564517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1159
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