H3K9/36me3 Demethylase KDM4A Promotes Site-Specific Copy Gain and Re-replication of Regions Amplified in Tumors

Acquired chromosomal instability and copy number alterations are hallmarks of cancer. Enzymes capable of promoting site-specific copy number changes have yet to be identified. Here, we demonstrate that H3K9/36me3 lysine demethylase KDM4A/JMJD2A overexpression leads to localized copy gain of 1q12, 1q...

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Bibliografiske detaljer
Main Authors: Black, Joshua C., Manning, Amity, Van Rechem, Capucine, Kim, Jaegil, Ladd, Brendon, Cho, Juok, Pineda, Cristiana M., Murphy, Nancy, Daniels, Danette L., Montagna, Cristina, Lewis, Peter W., Glass, Kimberly, Allis, C. David, Dyson, Nicholas J., Getz, Gad, Whetstine, Johnathan R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832053/
https://ncbi.nlm.nih.gov/pubmed/23871696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.06.051
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