H3K9/36me3 Demethylase KDM4A Promotes Site-Specific Copy Gain and Re-replication of Regions Amplified in Tumors

Acquired chromosomal instability and copy number alterations are hallmarks of cancer. Enzymes capable of promoting site-specific copy number changes have yet to be identified. Here, we demonstrate that H3K9/36me3 lysine demethylase KDM4A/JMJD2A overexpression leads to localized copy gain of 1q12, 1q...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Black, Joshua C., Manning, Amity, Van Rechem, Capucine, Kim, Jaegil, Ladd, Brendon, Cho, Juok, Pineda, Cristiana M., Murphy, Nancy, Daniels, Danette L., Montagna, Cristina, Lewis, Peter W., Glass, Kimberly, Allis, C. David, Dyson, Nicholas J., Getz, Gad, Whetstine, Johnathan R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832053/
https://ncbi.nlm.nih.gov/pubmed/23871696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.06.051
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы