Regulation of Transient Site-specific Copy Gain by MicroRNA

Intra-tumor copy number heterogeneity is commonly observed in cancer; however, the molecular mechanisms that contribute to heterogeneity remain poorly understood. Up-regulation of the histone demethylase KDM4A promotes transient site-specific copy gain (TSSG) in cells; therefore, uncovering how KDM4...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Black, Joshua C., Zhang, Hailei, Kim, Jaegil, Getz, Gad, Whetstine, Johnathan R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777823/
https://ncbi.nlm.nih.gov/pubmed/26755726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.711648
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