Hypoxia drives transient site-specific copy gain and drug-resistant gene expression

Copy number heterogeneity is a prominent feature within tumors. The molecular basis for this heterogeneity remains poorly characterized. Here, we demonstrate that hypoxia induces transient site-specific copy gains (TSSGs) in primary, nontransformed, and transformed human cells. Hypoxia-driven copy g...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Genes Dev
Päätekijät: Black, Joshua C., Atabakhsh, Elnaz, Kim, Jaegil, Biette, Kelly M., Van Rechem, Capucine, Ladd, Brendon, Burrowes, Paul d., Donado, Carlos, Mattoo, Hamid, Kleinstiver, Benjamin P., Song, Bing, Andriani, Grasiella, Joung, J. Keith, Iliopoulos, Othon, Montagna, Cristina, Pillai, Shiv, Getz, Gad, Whetstine, Johnathan R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2015
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441050/
https://ncbi.nlm.nih.gov/pubmed/25995187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.259796.115
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