Hypoxia drives transient site-specific copy gain and drug-resistant gene expression

Copy number heterogeneity is a prominent feature within tumors. The molecular basis for this heterogeneity remains poorly characterized. Here, we demonstrate that hypoxia induces transient site-specific copy gains (TSSGs) in primary, nontransformed, and transformed human cells. Hypoxia-driven copy g...

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Veröffentlicht in:Genes Dev
Hauptverfasser: Black, Joshua C., Atabakhsh, Elnaz, Kim, Jaegil, Biette, Kelly M., Van Rechem, Capucine, Ladd, Brendon, Burrowes, Paul d., Donado, Carlos, Mattoo, Hamid, Kleinstiver, Benjamin P., Song, Bing, Andriani, Grasiella, Joung, J. Keith, Iliopoulos, Othon, Montagna, Cristina, Pillai, Shiv, Getz, Gad, Whetstine, Johnathan R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441050/
https://ncbi.nlm.nih.gov/pubmed/25995187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.259796.115
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