EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells Against Ionizing Radiation

Therapeutics that target the epidermal growth factor receptor (EGFR) can enhance the cytotoxic effects of ionizing radiation (IR). However, predictive genomic biomarkers of this radiosensitization have remained elusive. By screening 40 non-small cell lung cancer cell (NSCLC) lines, we established a...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Wang, Meng, Kern, Ashley M., Hülskötter, Marieke, Greninger, Patricia, Singh, Anurag, Pan, Yunfeng, Chowdhury, Dipanjan, Krause, Mechthild, Baumann, Michael, Benes, Cyril H., Efstathiou, Jason A., Settleman, Jeff, Willers, Henning
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278592/
https://ncbi.nlm.nih.gov/pubmed/24648348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3157
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