EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells Against Ionizing Radiation

Therapeutics that target the epidermal growth factor receptor (EGFR) can enhance the cytotoxic effects of ionizing radiation (IR). However, predictive genomic biomarkers of this radiosensitization have remained elusive. By screening 40 non-small cell lung cancer cell (NSCLC) lines, we established a...

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Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Wang, Meng, Kern, Ashley M., Hülskötter, Marieke, Greninger, Patricia, Singh, Anurag, Pan, Yunfeng, Chowdhury, Dipanjan, Krause, Mechthild, Baumann, Michael, Benes, Cyril H., Efstathiou, Jason A., Settleman, Jeff, Willers, Henning
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278592/
https://ncbi.nlm.nih.gov/pubmed/24648348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3157
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