EGFR activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity

In lung cancer patients whose tumors harbor activating mutations in the epidermal growth factor receptor (EGFR), increased responses to platinum-based chemotherapies are seen compared to wild-type cancers. However, the mechanisms underlying this association have remained elusive. Here, we describe a...

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Detalhes bibliográficos
Main Authors: Pfäffle, Heike N., Wang, Meng, Gheorghiu, Liliana, Ferraiolo, Natalie, Greninger, Patricia, Borgmann, Kerstin, Settleman, Jeffrey, Benes, Cyril H., Sequist, Lecia V., Zou, Lee, Willers, Henning
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823187/
https://ncbi.nlm.nih.gov/pubmed/23966292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0044
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