Detection of Impaired Homologous Recombination Repair in NSCLC Cells and Tissues

INTRODUCTION: Homologous recombination repair (HRR) is a critical pathway for the repair of DNA damage caused by cisplatin or PARP inhibitors. HRR may be impaired by multiple mechanisms in cancer, which complicates assessing the functional HRR status in cells. Here, we monitored the ability of non-s...

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Hlavní autoři: Birkelbach, Moritz, Ferraiolo, Natalie, Gheorghiu, Liliana, Pfäffle, Heike N., Daly, Benedict, Ebright, Michael I., Spencer, Cheryl, O’Hara, Carl, Whetstine, Johnathan R., Benes, Cyril H., Sequist, Lecia, Zou, Lee, Dahm-Daphi, Jochen, Kachnic, Lisa A., Willers, Henning
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573529/
https://ncbi.nlm.nih.gov/pubmed/23399959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31827ecf83
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